Two series of the novel an aryl(heteryl)idene containing pyrazolo[3,4-d]pyrimidin-4-one targets (5a-o and 6a−o) were performed applying by the condensation of tricyclic pyrazolo[3,4-d]pyrimidin-4-ones (3 and 4) with the appropriate aromatic aldehydes in the basic condition. Some derivatives demonstrated AChE and BuChE inhibition