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SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE

Salieva G.B. 1, Jumaeva M.E. 1, Kholikov T.S. 1, Aisa H.A.2, Bozorov Kh.A. 1,2,


A convenient synthesis of novel tricyclic annulated pyrimidinone, namely 1-phenyl-

1,6,7,8-tetrahydro-4H-pyrazolo[3,4-d]pyrrolo[1,2-a]pyrimidin-4-one was described herein.

Cyclization was provided via A-ring modification of deoxyvasicinone (natural product). Biological

activities of this compound reveal promising acetylcholinesterase inhibitory activity of 82.48±0.76 %,

while showed moderate butyrylcholinesterase inhibitory activity



https://doi.org/10.59251/2181-1296.v1.1252.948

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