To synthesize new derivatives of quinazolinones by the Buchwald-Hartwig method, 6-bromo-quinazolin-4-one derivatives were initially synthesized using cyclization methods and converted into 6-bromoquinazolin-4-thiones using Lawesson's reagent. These thione derivatives were reacted with aromatic amines in the presence of appropriate bases, palladium catalysts, and solvents, their chemical properties were studied and optimal conditions were selected. The structures of the resulting new compounds were studied based on 1H NMR, 13C NMR, MS, and MP analyses