This article presents the results of the study of the effect of microelements on the leaf area, dry matter formation and yield of cotton in the conditions of the gray soils of the Zarafshan Valley. The optimal rate of application of microelements had a positive effect on the leaf area and dry mass of cotton plants.The highest result was observed when N250P175K125 +KUPRUMHITE+NANOSEREBRO kg/ha was applied with mineral fertilizer.